The Independent Spirituality Assessment Scale (iSAS) is a one of many spirituality measurement scales available. Its has shown transparency across different religions and denominations in the United States, and is most suitable to measure spirituality in the workplace (non-denominational approach). The iSAS demonstrated normality (p = 0.09, n = 234), homogeneity (a = 0.88, n = 508), and stability (r = 0.93, n = 28), with an improved homogeneity (a = 0.91) after refinements. Construct validity is demonstrated through two control groups, concurrency with two other spirituality instruments, namely Howden's © (r = 0.53, n = 220), and Beazley's © (r = 0.31, n = 113) scales, and also with a factor analysis. These statistical analyses are from a population of 508 respondents obtained from seven major metropolitan areas in five states.